# Circular dichroism studies of optically active Sh-derivates

Marzotto, A. and Nicolini, M. and Signor, A. (1970) Circular dichroism studies of optically active Sh-derivates. Accademia Peloritana dei Pericolanti - Classe di Scienze FF.MM.NN., L (1). pp. 73-77.

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S-dinitropyridyl and S-dinitrophenyl glutathione have been prepared in very mild conditions by reaction of gluthione with 2-chloro-3,5-dinitropyridine and 2,4-dinitrofluorobenzene respectively. The obtained compounds exhibit a strong ultraviolet absorption band near 330 nm. The circular dichroism spectra, measured in water in the wavelenght interval 200 to 400 nm, evidentiate strong interaction between the introduced chromophores and the asymmetric $\alpha$-carbon; the dichroic bands are centered around the same position of the ultraviolet maxima. It was also observed that aryl-substitution deeply influences the dichroic band of the parent derivative in the region of amide-bond absorption.