Lo Giudice, Mariateresa and Guarneri, C. (1998) Piebaldismo. Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche, LXXXVI (1). pp. 99-102.
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Abstract
Piebaldism is an uncommon, autosomal dominant, congenital, stable leukoderma associated with white forelock and hyperpigmented macules within vitiligo-like amelanotic macules. Melanin is absent from skin and hair bulbs. Dopa reaction is negative and melanocytes are absent in the white macules. Cytogenetic investigation disclosed a de novo unbalanced traslocation between chromosomes 4 and 18 with deletion of 4q12. Piebaldism result from mutations of the KIT protoncogene, which encodes the cell surface receptor transmembrana tyrosine kinase for an embrioyc growt factor, Steel factor. The treatments of piebaldism are a sun-protective agents, topical cosmetics and monobenzylether of hydroquinone (20%) to depigment the normal skin. Because there are as yet no other treatment options, depigmentation should be considered in any piebald who considers the condition significantly disfiguring.
| Item Type: | Article |
|---|---|
| Subjects: | M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Medico-Biologiche > 1998 M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Lettere Filosofia e belle Arti > 1998 |
| Depositing User: | Dr PP C |
| Date Deposited: | 07 Jan 2013 10:02 |
| Last Modified: | 22 Jan 2013 09:16 |
| URI: | http://cab.unime.it/mus/id/eprint/2875 |
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