Sindrome di Graham-Little-Piccardi-Lassueur

Manfrè, C. and Colella, V. and De Caridi, A. (2001) Sindrome di Graham-Little-Piccardi-Lassueur. Accademia Peloritana dei Pericolanti, Classe di Scienze Medico-Biologiche, LXXXIX. pp. 239-243.

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Abstract

A case of Graham-Litt1e-Piccardi-Lassueur syndrome in a 68 years old man is reported. Graham-Litt1e-Piccardi-Lassueur syndrome is make up by the triad: follicular papules, typical cutaneous or mucosal lichen planus and alopecia of the scalp with or without atrophy. The cause of lichen remains unknown. Evidence currently available suggests that lichen represents a reflection of a ce11-mediated immune response. The pathogenesis of lichen involves antigen presentation to helper T-ce1ls, activated T-ceil elaboration of IL2, interferon-gamma with subsequent recruiment of more T-ce1ls and induction of keratinocytes to produce cytokins. Cytotoxic T-cells, lymphotoxins and cytokines may mediate basal cell liquefaction and other keratinocyte damage. Cyclosporine A may induce a sustained remission.

Item Type: Article
Subjects: M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Medico-Biologiche > 2000-2001
Depositing User: Dr A F
Date Deposited: 08 Jan 2013 09:36
Last Modified: 08 Jan 2013 09:36
URI: http://cab.unime.it/mus/id/eprint/3025

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