Manfrè, C. and Colella, V. and De Caridi, A. (2001) Sindrome di Graham-Little-Piccardi-Lassueur. Accademia Peloritana dei Pericolanti, Classe di Scienze Medico-Biologiche, LXXXIX. pp. 239-243.
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A case of Graham-Litt1e-Piccardi-Lassueur syndrome in a 68 years old man is reported. Graham-Litt1e-Piccardi-Lassueur syndrome is make up by the triad: follicular papules, typical cutaneous or mucosal lichen planus and alopecia of the scalp with or without atrophy. The cause of lichen remains unknown. Evidence currently available suggests that lichen represents a reflection of a ce11-mediated immune response. The pathogenesis of lichen involves antigen presentation to helper T-ce1ls, activated T-ceil elaboration of IL2, interferon-gamma with subsequent recruiment of more T-ce1ls and induction of keratinocytes to produce cytokins. Cytotoxic T-cells, lymphotoxins and cytokines may mediate basal cell liquefaction and other keratinocyte damage. Cyclosporine A may induce a sustained remission.
|Subjects:||M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Medico-Biologiche > 2000-2001|
|Depositing User:||Dr A F|
|Date Deposited:||08 Jan 2013 10:36|
|Last Modified:||08 Jan 2013 10:36|
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