Borgia, F. and Vaccaro, M. and Guarneri, C. and Cannavò, S. P. (1999) Infiltrazione linfocitaria benigna di Jessner-Kanof. Accademia Peloritana dei Pericolanti Classe scienze medico - biologiche, 87. pp. 41-51.
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Lymphocytic infiltration of the skin is a chronic, benign pathology, included in the spectrum of cutaneous pseudolymphoma, characterized, clinically, by peripherally enlarging, eritematous papules and plaques that may show central clearing.
Since the first description by Jessner and Kanof, there has been continued controversy about its nature; it is considered by many to be a distinct entity, but others regard it as an initial or variant stage of LECD, polymorphic light eruption or cutaneous lymphoma.
Skin biopsy specimens show well-circumscribed perivascular aggregates of lymphocytes in the papillary and mi-dermis; the epidermis appears normal, and there is no thickening of the basament membrane at the dermo-epidermal junction.
Immunohistochemical studies have demonstrated a T-cell immunophenotype.
An effective and harmless therapy is not yet available; a recent study reports good result with thalidomide, but long-term risk-benefit ratio has still to be evaluated.
|Subjects:||M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Medico-Biologiche > 1999|
M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Giuridiche, Economiche e Politiche > 1999
M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Lettere, Filosofia e belle Arti > 1999
|Depositing User:||Dr M P|
|Date Deposited:||31 Jan 2013 09:55|
|Last Modified:||03 Apr 2013 11:38|
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