Messanae Universitas Studiorum

Structural features of a new class of non nucleoside HIV-1 RT inhibitors

Bruno, G. and Nicolò, F. and Scopelliti, R. and Chimiri, A. (1994) Structural features of a new class of non nucleoside HIV-1 RT inhibitors. Accademia Peloritana dei Pericolanti Classe FF.MM.NN., LXXII (Supplement 1). pp. 349-352.

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Abstract

The crystal structures of a new pharmacologicai class of HIV-1 inhibitors are reported. Of a large series of thiazolobenzimidazoles the TBZ (1-(2’,6’difluorophenyl)-1H, 3H-thiazolo[3,4-a] benzimidazole {NSC 625487} is a highly potent inhibitor of human immunodeficiency virus-induced cell killing and viral replication in a variety of human cell lines at concentrations not cytotoxic to the host cells. All the compounds assume a butterfiylike conformation that appears particulariy important in RT inhibitors

Item Type: Article
Subjects: M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Fisiche, Matematiche e Naturali > 1994 > Supplemento 1 parte 1
M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Medico-Biologiche > 1994 > Supplemento 1 parte 1
M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Giuridiche, Economiche e Politiche > 1994 > Supplemento 1 parte 1
M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Lettere, Filosofia e belle Arti > 1994 > Supplemento 1 parte 1
Depositing User: Mr Nunzio Femminò
Date Deposited: 02 Apr 2014 14:53
Last Modified: 02 Apr 2014 14:54
URI: http://cab.unime.it/mus/id/eprint/5153

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