Bruno, G. and Nicolò, F. and Scopelliti, R. and Chimiri, A. (1994) Structural features of a new class of non nucleoside HIV-1 RT inhibitors. Accademia Peloritana dei Pericolanti Classe FF.MM.NN., LXXII (Supplement 1). pp. 349-352.
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Abstract
The crystal structures of a new pharmacologicai class of HIV-1 inhibitors are reported. Of a large series of thiazolobenzimidazoles the TBZ (1-(2’,6’difluorophenyl)-1H, 3H-thiazolo[3,4-a] benzimidazole {NSC 625487} is a highly potent inhibitor of human immunodeficiency virus-induced cell killing and viral replication in a variety of human cell lines at concentrations not cytotoxic to the host cells. All the compounds assume a butterfiylike conformation that appears particulariy important in RT inhibitors
| Item Type: | Article |
|---|---|
| Subjects: | M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Fisiche, Matematiche e Naturali > 1994 > Supplemento 1 parte 1 M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Medico-Biologiche > 1994 > Supplemento 1 parte 1 M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Giuridiche, Economiche e Politiche > 1994 > Supplemento 1 parte 1 M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Lettere Filosofia e belle Arti > 1994 > Supplemento 1 parte 1 |
| Depositing User: | Mr Nunzio Femminò |
| Date Deposited: | 02 Apr 2014 14:53 |
| Last Modified: | 02 Apr 2014 14:54 |
| URI: | http://cab.unime.it/mus/id/eprint/5153 |
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