Messanae Universitas Studiorum

Plasma Concentrations of Risperidone and Olanzapine during
Coadministration with Oxcarbazepine

Muscatello, Maria R. A. and Pacetti, Monica and Cacciola, Massimo and La Torre, Diletta and Zoccali, Rocco A. and D'Arrigo, Concetta and Migliardi, Gaetana and Spina, Edoardo (2005) Plasma Concentrations of Risperidone and Olanzapine during
Coadministration with Oxcarbazepine.
Epilepsia, 46 (5). pp. 771-774. ISSN 0013-9580

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    Abstract

    Purpose: Oxcarbazepine (OZC) is a secondgeneration
    antiepileptic drug (AED) that also may be used as
    a mood stabilizer. Unlike carbamazepine (CBZ), which is an
    inducer of the cytochrome P-450 isoforms and may accelerate
    the elimination of several therapeutic agents, OXC seems
    to have only a modest inducing action. The aim of this investigation was to evaluate the effect of a treatment with OXC on plasma concentrations of the new antipsychotics risperidone and olanzapine.
    Methods: OXC, at a dosage of 900–1,200 mg/day, was administered for 5 consecutive weeks to 25 outpatients, 10 men and 15 women, aged 25 to 64 years, with bipolar or schizoaffective disorder. Twelve patients were stabilized on risperidone therapy (2–6 mg/day) and 13 on olanzapine (5–20 mg/day). Steady-state plasma concentrations of risperidone and its active metabolite 9-hydroxyrisperidone (9-OH-risperidone) and olanzapine were
    measured by high-pressure liquid chromatography (HPLC) before addition of OXC and after 5 weeks from the start of adjunctive treatment.
    Results:OXC caused only minimal and no significant changes
    in the mean plasma levels of risperidone (from 5.6±3.6 ng/ml at baseline to 4.8 ± 2.6 ng/ml at week 5), 9-OH-risperidone (from 23.6±7.5 to 24.7±7.4 ng/ml), and olanzapine (from 26.5±5.7 ng/ml at baseline to 27.8 ± 5.1 ng/ml). OXC coadministration with either risperidone or olanzapine was well tolerated.
    Conclusions: Our findings indicate that OXC does not affect
    the elimination of risperidone and olanzapine, thus confirming its weak inducing effect on hepatic drug-metabolizing
    enzymes.

    Item Type: Article
    Uncontrolled Keywords: Oxcarbazepine; Risperidone; Olanzapine; Drug interaction
    Subjects: M.U.S. - Contributi Scientifici > 06 - Scienze mediche
    Divisions: UNSPECIFIED
    Depositing User: Mr Nunzio Femminò
    Date Deposited: 08 Oct 2009
    Last Modified: 03 Apr 2013 11:54
    URI: http://cab.unime.it/mus/id/eprint/518

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