Messanae Universitas Studiorum

Degenerated Bogdanov-Takens bifurcations in an immuno-tumor model

Trifan, Mariana P. and Georgescu, Adelina (2009) Degenerated Bogdanov-Takens bifurcations in an immuno-tumor model. Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze MM.FF.NN., LXXXVII (1). ISSN 1825-1242


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A mathematical immuno-tumor model proposed by A. Kavaliauskas [Nonlinear Anal. Model. Control 8, 55 (2003)] and consisting of a Cauchy problem for a system of two first-order ordinary differential equations is studied. For some particular parameters values, this model has saddle-node, Hopf and Bogdanov-Takens (BT) singularities. In the case of the BT singularities, we herein derive the normal forms of the governing equations by using ideas and a method from S.-N. Chow, C. Li, and D. Wang [Normal forms and bifurcation of planar vector fields (1994)] and Yu. A. Kuznetsov [Elements of applied bifurcation theory (1994)], based on an appropriate splitting of associated Hilbert spaces. It is found that a limit case of parameters associated with medicine administration corresponds to degenerate BT bifurcations and, so, to a large variety of responses to the medical treatments for admissible parameters near the limit ones.

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Item Type: Article
Subjects: M.U.S. - Contributi Scientifici > 02 - Scienze fisiche
M.U.S. - Miscellanea > Atti Accademia Peloritana > Classe di Scienze Fisiche, Matematiche e Naturali
Depositing User: Mr Nunzio Femminò
Date Deposited: 26 Nov 2009
Last Modified: 13 Apr 2010 11:14

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