Thermodynamics and SARS-CoV-2: neurological effects in post-Covid 19 syndrome

Umberto Lucia, Giulia Grisolia, Thomas S. Deisboeck


There is increasing evidence that infection with SARS-CoV-2 can cause a spectrum of neurological symptoms. In this paper, we develop a theoretical concept underlying such neurological COVID-19 consequences by employing a non-equilibrium thermodynamic approach that allows linking the neuronal electric potential with a virus-induced pH variation. Our theoretical findings support further experimental work on therapeutically correcting electrolyte imbalances, such as Na+ and K+, to attenuate the neurological effects of SARS-CoV-2.


Irreversible thermodynamics; Membrane potential; Neurological effects; Post-Covid Syndrome; SARS-CoV-2.

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Copyright (c) 2021 Umberto Lucia, Giulia Grisolia, Thomas S. Deisboeck

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