A case of thymoma mimicking an intra-thoracic thyroid nodule

Cristina Pizzimenti, Giovanni Tuccari, Antonio Ieni, Francesca Mazzeo, Gianlorenzo Dionigi, Guido Fadda


Thymomas are rare malignant tumour of the superior and anterior mediastinum. We report the case of a 77-year-old woman with a mediastinal nodule of uncertain origin. The clinical history of the patient and the imaging findings were suggestive of a lesion of thyroid origin. Histological and immunohistochemical analysis led to a histological diagnosis of thymoma with microscopic invasion of the surrounding tissue


thymoma, mediastinal masses, ectopic thyroid goiter, differential diagnosis

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1. Markowiak, T., Hofmann, H.S., Ried M. (2020). Classification and staging of thymoma. J Thorac Dis, 12(12):7607–12. doi: 10.21037/jtd-2019-thym-01

2. Engels, E.A. (2010). Epidemiology of thymoma and associated malignancies. J Thorac Oncol, 5 (10 Suppl 4):S260-5. doi: 10.1097/JTO.0b013e3181f1f62d.

3. Scorsetti, M., Leo, F., Trama, A., D'Angelillo, R., Serpico, D., Macerelli, M., Zucali, P., Gatta, G., Garassino, M.C. (2016). Thymoma and thymic carcinomas. Crit Rev Oncol Hematol, 99:332-50. doi: 10.1016/j.critrevonc.2016.01.012

4. Duwe, B.V., Sterman, D.H., Musani, A.I. (2005) Tumors of the mediastinum. Chest, 128(4):2893-909. doi: 10.1378/chest.128.4.2893.

5. Patel, K.M., Parsons, C.C. (2016) Forgotten goiter: Diagnosis and management. A case report and literature review. Int J Surg Case Rep, 27:192-194. doi: 10.1016/j.ijscr.2016.08.036.

6. Juanpere, S., Cañete, N., Ortuño, P., Martínez, S., Sanchez, G., Bernado, L. (2013) A diagnostic approach to the mediastinal masses. Insights Imaging, 4(1):29-52. doi: 10.1007/s13244-012-0201-0.

7. den Bakker, M.A., Roden, A.C., Marx, A., Marino, M. (2014). Histologic classification of thymoma: a practical guide for routine cases. J Thorac Oncol, 9(9 Suppl 2):S125-30. doi: 10.1097/JTO.0000000000000297.

8. Marx, A., Chan, J.K., Coindre, J.M., Detterbeck, F., Girard, N., Harris, N.L., Jaffe, E.S., Kurrer, M.O., Marom, E.M., Moreira, A.L., Mukai, K., Orazi, A., Ströbel, P. (2015) The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes. J Thorac Oncol, 10(10):1383-95. doi: 10.1097/JTO.0000000000000654.

9. Detterbeck, F.C., Nicholson, A.G., Kondo, K., Van Schil, P., Moran, C. (2011) The Masaoka-Koga stage classification for thymic malignancies: clarification and definition of terms. J Thorac Oncol, 6(7 Suppl 3):S1710-6. doi: 10.1097/JTO.0b013e31821e8cff.

Ried, M., Eicher, M.M., Neu, R., Sziklavari, Z., Hofmann, H.S. (2017). Evaluation of the new TNM-staging system for thymic malignancies: impact on indication and survival. World J Surg Oncol. 2017 Dec 2;15(1):214. doi: 10.1186/s12957-017-1283-4.

DOI: https://doi.org/10.13129/1828-6550/APMB.109.2.2021.CCS2


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