A case of pleural empyema treated with intrapleuralurokinase

Federica Xerra, Immacolata Rulli, Mauro Iannelli, Antonella Gambadauro, Francesca Galletta, Monica Fusco, Simona Allera, Sara Manti, Carmelo Romeo, Francesco Monaco, Eloisa Gitto

Abstract


Pleural empyema, a severe complication of bacterial pneumonia, is a rare entity in the neonatal period. Treatment with systemic antibiotics and tube drainage may fail because of the thick viscous fluid, bacterial products with fibrin deposition, and multiple involvement. Intrapleural fibrinolytic therapy with urokinase is an effective and non-invasive treatment option that avoids surgical intervention, although its use in neonates has not been studied extensively. In this report, we describe the case of a 39-day-old male newborn with pneumonia and pleural empyema, treated successfully with antibiotics, chest tube drainage and intrapleuralurokinase.

Keywords


pleural empyema; newborn; intrapleuralurokinase

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References


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Diez, J.R.V., Perez, M.L.M., Malayan, G.V., Cenabre, M.V.L. (2020). Loculated empyema in a neonate successfully treated with chest tube thoracostomy and antibiotics. Respir Med Case Rep. doi:10.1016/j.rmcr.2020.10127




DOI: https://doi.org/10.13129/1828-6550/APMB.111.1.2023.CCS2

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Copyright (c) 2023 Federica Xerra, Immacolata Rulli, Mauro Iannelli, Antonella Gambadauro, Francesca Galletta, Monica Fusco, Simona Allera, Sara Manti, Carmelo Romeo, Francesco Monaco, Eloisa Gitto

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