New-onset Intermittent Explosive Disorder (IED); metabolic and clinical correlates: Case report

Giuseppina Selene Spina, Maria Rosaria Anna Muscatello, Domenica Campolo, Mariachiara Zanotti


This paper presents the correlation between Intermittent Explosive Disorder (IED), listed in the domain of Disruptive, Impulse-Control and Conduct Disorders in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM 5), and metabolic alterations. A 64-years-old man with no previous history of major psychiatric disorders, presenting an onset of IED almost concomitant with the diagnosis of diabetes mellitus and dyslipidemia, is assessed upon a clinical and neuropsychological evaluation. Authors emphasize the influence of metabolic alterations and liver disease in the manifestation of impulsive aggression and violent behaviour, suggesting a multidisciplinary approach of those patients who present IED and concomitant metabolic alterations.


Intermittent Explosive Disorder; Diabetes Mellitus; Metabolic alterations

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