Quality of life in postmenopausal women: which role for vitamin D?

Gabriella Martino, Antonino Catalano, Federica Bellone, Viviana Langher, Carmen Lasco, Assunta Penna, Giacomo Nicocia, Nunziata Morabito


Quality of life (QoL) represents a dramatic issue in an aging population. Vitamin D has been consistently associated with several diseases. Thus, vitamin D may be considered a hallmark of health status. Our aim was to investigate whether vitamin D could be a determinant of self-perceived quality of life.

The 36-Item Short Form Health Survey (SF-36) for quality of life, the Hamilton Anxiety Rating Scale (HAM-A), the Beck Depression Inventory II edition (BDI-II), in addition with multiple clinical risk factors for fractures and FRAX score, BMD at lumbar spine and femoral neck, were evaluated in a group of 177 postmenopausal women referring to an outpatients clinic for the prevention of osteoporosis.

Serum levels of vitamin D [25(OH)D], indicative of vitamin D status, were detected by high-performance liquid chromatography.

Scores of each dimension of the SF-36 were significantly related with the measurements of anxiety and depression by HAM-A and BDI-II respectively. Moreover role emotional, vitality, general health and bodily pain were significantly associated with vitamin D status. However, at a stepwise multiple regression analysis the physical component summary, obtained from SF-36, was not independently predicted from vitamin D.

In conclusion we found an association between vitamin D status and QoL, thus we suggest physicians to consider vitamin D levels as a marker of QoL.

Further studies testing the impact of vitamin D administration in improving QoL over time are needed.


Quality of life; Vitamin D; Anxiety; Depression; Osteoporosis; Vitality

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DOI: https://doi.org/10.6092/2282-1619/2018.6.1875


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