Traumatic potential of Recurrent Implantation Failure in Assisted Reproductive Technology paths for couples experiencing infertility

Chiara Fusco, Pier Luigi Righetti, Camilla Pellicelli, Chiara Masaro, Silvia Longo, Vincenzo Calvo

Abstract


Heterosexual couples dealing with infertility can seek Assisted Reproductive Technology (ART) treatments to achieve pregnancy. Within these programs, infertile couples can experience Recurrent Implantation Failure (RIF), which is the failure to achieve a clinical pregnancy after three or more transfers of good-quality embryos into the uterus. RIF also refers to cases of biochemical pregnancy in which increased levels of Beta hCG hormone are detected without subsequent signs of clinical pregnancy.


Although the psychological literature has shown that the repetition of ART attempts significantly correlates with negative psychological outcomes for men and women, to date there are no studies regarding the potentially traumatic features of RIF experiences.


Hence, we provide an overview of the extant literature to highlight points of contact between the features of traumatic experiences and those of RIF and infertility, including the specific characteristics that make the population of infertile couples in ART programs potentially more vulnerable to trauma. This article aims to stimulate reflection in this area and emphasize the importance of expanding research to deepen our knowledge of the psychological processes involved in RIF conditions within ART treatments for infertile couples.

Keywords


Recurrent Implantation Failure; Infertility; Assisted Reproductive Technology; Couple; Reproductive Trauma.

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References


Andrews, F. M., Abbey, A., & Jill Halman, L. (1992). Is fertility-problem stress different? The dynamics of stress in fertile and infertile couples*†. Fertility and Sterility, 57(6), 1247–1253.https://doi.org/10.1016/S0015-0282(16)55082-1

APA, American Psychological Association. (2022). Trauma. Retrieved from: https://dictionary.apa.org/trauma

Argentieri, S. (2014). Nuove genitorialità? Quaderni Degli Argonauti, 27, 49–59.

Bashiri, A., Halper, K. I., & Orvieto, R. (2018). Recurrent Implantation Failure—Update overview on etiology, diagnosis, treatment and future directions. Reproductive Biology and Endocrinology, 16(1), 121.https://doi.org/10.1186/s12958-018-0414-2

Benyamini, Y., Gozlan, M., & Kokia, E. (2009). Women’s and men’s perceptions of infertility and their associations with psychological adjustment: A dyadic approach. British Journal of Health Psychology, 14(1), 1–16.https://doi.org/10.1348/135910708X279288

Bhat, A., & Byatt, N. (2016). Infertility and Perinatal Loss: When the Bough Breaks. Current Psychiatry Reports, 18(3), 31.https://doi.org/10.1007/s11920-016-0663-8

Boivin, J., & Takefnan, J. E. (1996). Impact of the in-vitro fertilization process on emotional, physical and relational variables. Human Reproduction, 11(4), 903-907. https://doi.org/10.1093/oxfordjournals.humrep.a019276

Boivin, J., Bunting, L., Collins, J. A., & Nygren, K. G. (2007). International estimates of infertility prevalence and treatment-seeking: Potential need and demand for infertility medical care. Human Reproduction, 22(6), 1506–1512.https://doi.org/10.1093/humrep/dem046

Burnham, J. (2012) Developments in Social GRRRAAACCEEESSS: visible – invisible and voiced – unvoiced. In I.-B. Krause, (ed.) Culture and Reflexivity in Systemic Psychotherapy: Mutual Perspectives (pp. 139–160). London: Karnac.

Burns, L. H. (2007). Psychiatric Aspects of Infertility and Infertility Treatments. Psychiatric Clinics of North America, 30(4), 689–716.https://doi.org/10.1016/j.psc.2007.08.001

Calvo, V., Masaro, C., and Fusco, C. (2021). Attachment and emotion regulation across the life cycle [Attaccamento e regolazione emozionale nel ciclo di vita]. Giornale italiano di psicologia, 48, 761–766. 10.1421/103764

Calvo, V., Fusco, C., Pellicelli, C., & Masaro, C. (2022). Romantic attachment, infertility-related stress, and positive body image of women dealing with infertility. Frontiers in Psychology, 13.https://doi.org/10.3389/fpsyg.2022.1067970

Cipolletta, S., & Faccio, E. (2013). Time experience during the assisted reproductive journey: A phenomenological analysis of Italian couples’ narratives. Journal of Reproductive and Infant Psychology, 31(3), 285–298. https://doi.org/10.1080/02646838.2013.813627

Clarke, L. H., Martin-Matthews, A., & Matthews, R. (2006). The Continuity and Discontinuity of the Embodied Self in Infertility*. Canadian Review of Sociology/Revue Canadienne de Sociologie, 43(1), 95–113.https://doi.org/10.1111/j.1755-618X.2006.tb00856.x

Coughlan, C., Ledger, W., Wang, Q., Liu, F., Demirol, A., Gurgan, T., Cutting, R., Ong, K., Sallam, H., & Li, T. C. (2014). Recurrent implantation failure: Definition and management. Reproductive BioMedicine Online, 28(1), 14–38.https://doi.org/10.1016/j.rbmo.2013.08.011

Coughlan, C., Walters, S., Ledger, W., & Li, T. C. (2014). A comparison of psychological stress among women with and without reproductive failure. International Journal of Gynecology and Obstetrics, 124, 143–147.

Cousineau, T. M., & Domar, A. D. (2007). Psychological impact of infertility. Best Practice & Research Clinical Obstetrics & Gynaecology, 21(2), 293–308. https://doi.org/10.1016/j.bpobgyn.2006.12.003

Daugirdaitė, V., van den Akker, O., & Purewal, S. (2015). Posttraumatic Stress and Posttraumatic Stress Disorder after Termination of Pregnancy and Reproductive Loss: A Systematic Review. Journal of Pregnancy, 2015, 1–14.https://doi.org/10.1155/2015/646345

Donarelli, Z., Kivlighan, D. M., Adolfo, A., & Coco, G. L. (2016). How do individual attachment patterns of both members of couples affect their perceived infertility stress? An actor–partner interdependence analysis. Personality and Individual Differences, 92, 63–68.https://doi.org/10.1016/j.paid.2015.12.023

Dunkel-Schetter, C., & Lobel, M. (1991). Psychological Reactions to Infertility. In A. L. Stanton & C. Dunkel-Schetter (Eds.), Infertility (pp. 29–57). Springer US.https://doi.org/10.1007/978-1-4899-0753-0_3

El Kissi, Y., Romdhane, A. B., Hidar, S., Bannour, S., Ayoubi Idrissi, K., Khairi, H., & Ben Hadj Ali, B. (2013). General psychopathology, anxiety, depression and self-esteem in couples undergoing infertility treatment: A comparative study between men and women. European Journal of Obstetrics & Gynecology and Reproductive Biology, 167(2), 185–189.https://doi.org/10.1016/j.ejogrb.2012.12.014

ESHRE, European Society of Human Reproduction and Embryology. (2022). ART, Assisted Reproductive Technology (Fact Sheet). Retrieved from:https://www.eshre.eu/Press-Room/Resources

Frederiksen, Y., Farver-Vestergaard, I., Skovgard, N. G., Ingerslev, H. J., & Zachariae, R. (2015). Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: A systematic review and meta-analysis. BMJ Open, 5(1), e006592–e006592.https://doi.org/10.1136/bmjopen-2014-006592

Fusco, C., Masaro, C., & Calvo, V. (2023). ‘I feel like I was born for something that my body can’t do’: a qualitative study on women’s bodies within medicalized infertility in Italy. Psychology & Health, 1-20. https://doi.org/10.1080/08870446.2023.2180148

Gaitzsch, H., Benard, J., Hugon-Rodin, J., Benzakour, L., & Streuli, I. (2020). The effect of mind-body interventions on psychological and pregnancy outcomes in infertile women: A systematic review. Archives of Women’s Mental Health, 23(4), 479–491.https://doi.org/10.1007/s00737-019-01009-8

Gameiro, S., van den Belt-Dusebout, A. W., Smeenk, J. M. J., Braat, D. D. M., van Leeuwen, F. E., & Verhaak, C. M. (2016). Women’s adjustment trajectories during IVF and impact on mental health 11–17 years later. Human Reproduction, 31(8), 1788–1798.https://doi.org/10.1093/humrep/dew131

Greil, A. L. (1991). A secret stigma: The analogy between infertility and chronic illness and disability. Advances in Medical Sociology, 2, 17–38.

Greil, A. L. (1997). Infertility and psychological distress: A critical review of the literature. Social Science & Medicine, 45(11), 1679–1704.https://doi.org/10.1016/S0277-9536(97)00102-0

Greil, A. L. (2002). Infertile Bodies: Medicalisation, Metaphor, and Agency. In Infertility around the Globe: New Thinking on Childlessness, Gender, and Reproductive Technologies, edited by Marcia C. Inhorn and Frank Van Balen (pp. 101–118). University of California Press.

Homer, C. S. E., Malata, A., & ten Hoope-Bender, P. (2016). Supporting women, families, and care providers after stillbirths. The Lancet, 387(10018), 516–517.https://doi.org/10.1016/S0140-6736(15)01278-7

ISS, National Institute of Health in Italy. (2022). Infertility. National Institute of Health in Italy. Retrieved from:https://www.iss.it/en/infertilità-e-MAR

Italian Register of Medically Assisted Procreation. (2021). Report of the Minister of Health to Parliament on the status of implementation of the law containing regulations on medically assisted procreation—Year 2021. Italian Ministry of Health. Retrieved from:https://www.salute.gov.it/portale/donna/dettaglioPubblicazioniDonna.jsp?id=3162

Kim, M., Kim, S., Chang, S., Yoo, J.-S., Kim, H. K., & Cho, J. H. (2014). Effect of a Mind-Body Therapeutic Program for Infertile Women Repeating In Vitro Fertilization Treatment on Uncertainty, Anxiety, and Implantation Rate. Asian Nursing Research, 8(1), 49–56.https://doi.org/10.1016/j.anr.2014.02.002

Labadini, C., Righetti, P. L., Berlocchi, N., & Rubini, V. (2004). L’infertilità nella coppia: L’impatto sulla sessualità e mascolinità dell’uomo infertile. Nuove Tendenze Della Psicologia, Edizioni Erikson, 2(2), 245–264.

Langher, V., Fedele, F., Caputo, A., Marchini, F., & Aragona, C. (2019). Extreme desire for motherhood: Analysis of narratives from women undergoing Assisted Reproductive Technology (ART). Europe’s Journal of Psychology, 15(2), 292–311.https://doi.org/10.5964/ejop.v15i2.1736

Loftus, J., & Andriot, A. L. (2012). “That’s What Makes a Woman”: Infertility and Coping with a Failed Life Course Transition. Sociological Spectrum, 32(3), 226–243.https://doi.org/10.1080/02732173.2012.663711

Maesawa, Y., Yamada, H., Deguchi, M., & Ebina, Y. (2015). History of biochemical pregnancy was associated with the subsequent reproductive failure among women with recurrent spontaneous abortion. Gynecological Endocrinology, 31(4), 306–308.https://doi.org/10.3109/09513590.2014.994601

Manfredi, P., & Tomasi, C. (2022). Parenthood as an Opportunity to Mature: A Questionnaire to Detect Changes in Self-image and Relationships. Mediterranean Journal of Clinical Psychology, 10(3).https://doi.org/10.13129/2282-1619/mjcp-3298

Maroufizadeh, S., Karimi, E., Vesali, S., & Omani Samani, R. (2015). Anxiety and depression after failure of assisted reproductive treatment among patients experiencing infertility. International Journal of Gynecology and Obstetrics, 130, 253–256.

Myles, L., Connolly, J., & Stanulewicz, N. (2020). The Mediating Role of Perceived Control and Desire for Control in the Relationship between Personality and Depression. Mediterranean Journal of Clinical Psychology, 8(3). https://doi.org/10.6092/2282-1619/mjcp-2589

Myles, L., & Merlo, E. (2022a). Incongruities between Perceived Control and Desire for Control: A Mechanistic Account of Depression in Adolescence. Psychiatria i Psychologia Kliniczna, 22(1), 40-44. https://doi.org/10.15557/PiPK.2022.0005

Myles, L., & Merlo, E. (2022b). Elucidating the Cognitive Mechanisms Underpinning the Therapeutic Efficacy of Behavioural Activation. International Journal of Psychological Research, 15(1), 126-132. https://doi.org/10.21500/20112084.5400

Myles, L., Merlo, E., & Obele, A. (2021). Desire for Control Moderates the Relationship between Perceived Control and Depressive Symptomology. Journal of Mind and Medical Sciences, 8(2), 229-305. https://doi.org/10.22543/7674.82.P299305

Ni, Y., Tong, C., Huang, L., Zhou, W., & Zhang, A. (2021). The analysis of fertility quality of life and the influencing factors of patients with repeated implantation failure. Health and Quality of Life Outcomes, 19(1), 32.https://doi.org/10.1186/s12955-021-01666-3

Orvieto, R., Brengauz, M., & Feldman, B. (2015). A novel approach to normal responder patient with repeated implantation failures – a case report. Gynecological Endocrinology, 31(6), 435–437.https://doi.org/10.3109/09513590.2015.1005595

Park, N. K., & Wonch Hill, P. (2014). Is Adoption an Option? The Role of Importance of Motherhood and Fertility Help-Seeking in Considering Adoption. Journal of Family Issues, 35(5), 601–626.https://doi.org/10.1177/0192513X13493277

Pasch, L. A., & Sullivan, K. T. (2017). Stress and coping in couples facing infertility. Current Opinion in Psychology, 13, 131–135.https://doi.org/10.1016/j.copsyc.2016.07.004

Riccio, M. (2017). La cicogna distratta. Il paradigma sistemico-relazionale nella clinica della sterilità e dell’infertilità di coppia. FrancoAngeli, Milano.

Righetti, P. L., & Luisi, S. (2007). La procreazione assistita. Aspetti psicologici e medici. Bollati Boringhieri, Torino.

Righetti, P. L., Zampieri, M. C., Ciampa, R., Baffoni, A., Benazzi, F., & Salemi, M. (2016). Assisted Reproduction Techniques: New Children, New Families. JSM Invitro Fertil, 1(1), 1005.

Schmidt, L., Holstein, B., Christensen, U., & Boivin, J. (2005). Does infertility cause marital benefit? Patient Education and Counseling, 59(3), 244–251.https://doi.org/10.1016/j.pec.2005.07.015

Scott, J. (2011). Stillbirths: Breaking the silence of a hidden grief. The Lancet, 377(9775), 1386–1388.https://doi.org/10.1016/S0140-6736(11)60107-4

Slade, P., O’Neill, C., Simpson, A. J., & Lashen, H. (2007). The relationship between perceived stigma, disclosure patterns, support and distress in new attendees at an infertility clinic. Human Reproduction, 22(8), 2309–2317.https://doi.org/10.1093/humrep/dem115

Straussner, S. L. A., & Calnan, A. J. (2014). Trauma Through the Life Cycle: A Review of Current Literature. Clinical Social Work Journal, 42(4), 323–335.https://doi.org/10.1007/s10615-014-0496-z

Swanson, A., & Braverman, A. M. (2021). Psychological Components of Infertility. Family Court Review, 59(1), 67–82.https://doi.org/10.1111/fcre.12552

Tao, P., Coates, & Maycock. (2011). The impact of infertility on sexuality: A literature review. Australasian Medical Journal, 4(11), 620–627.https://doi.org/10.4066/AMJ.2011.1055

Thompson, C. (2005). Making parents: The ontological choreography of reproductive technologies. MIT Press.

Van Der Kolk, B. (2015). Il corpo accusa il colpo. Mente, corpo e cervello nell’elaborazione delle memorie traumatiche. Trad. It. Francavilla e Patti (ed. Orig. The body Keeps the score, Penguin Group, 2014). Raffaello Cortina Editore.

Van Der Merwe, E., & Greeff, A. P. (2015). Infertility-Related Stress within the Marital Relationship. International Journal of Sexual Health, 27(4), 522–531.https://doi.org/10.1080/19317611.2015.1067275

Vander Borght, M., & Wyns, C. (2018). Fertility and infertility: Definition and epidemiology. Clinical Biochemistry, 62, 2–10.https://doi.org/10.1016/j.clinbiochem.2018.03.012

WHO, World Health Organization. (2013). Mental Health Action Plan 2013-2020. Retrieved from: https://www.salute.gov.it/imgs/C_17_pubblicazioni_2448_allegato.pdf

Wirtberg, I., Moller, A., Hogstrom, L., Tronstad, S.-E., & Lalos, A. (2006). Life 20 years after unsuccessful infertility treatment. Human Reproduction, 22(2), 598–604.https://doi.org/10.1093/humrep/del401

Yong, P., Martin, C., & Thong, J. (2000). A comparison of psychological functioning in women at different stages of in vitro fertilization treatment using the mean affect adjective check list. Journal of assisted reproduction and genetics, 17, 553-556. https://doi.org/10.1023/A:1026429712794

Zegers-Hochschild, F., Adamson, G. D., Dyer, S., Racowsky, C., de Mouzon, J., Sokol, R., Rienzi, L., Sunde, A., Schmidt, L., Cooke, I. D., Leigh Simpson, J., & van der Poel, S. (2017). The International Glossary on Infertility and Fertility Care, 2017. Human Reproduction, 32(9), 1786–1801.https://doi.org/doi:10.1093/humrep/dex234

Zurlo, M. C., Cattaneo Della Volta, M. F., & Vallone, F. (2018). Predictors of quality of life and psychological health in infertile couples: The moderating role of duration of infertility. Quality of Life Research, 27(4), 945–954.https://doi.org/10.1007/s11136-017-1781-4

Zurlo, M. C., Cattaneo Della Volta, M. F., & Vallone, F. (2019). Infertility-Related Stress and Psychological Health Outcomes in Infertile Couples Undergoing Medical Treatments: Testing a Multi-dimensional Model. Journal of Clinical Psychology in Medical Settings, 27, 662–676.https://doi.org/10.1007/s10880-019-09653-z




DOI: https://doi.org/10.13129/2282-1619/mjcp-3594

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