BRCA genetic result disclosure for women with Breast Cancer: influence of +/- predisposition genetic mutation

Jessica Ranieri, Federica Guerra, Eleonora Cilli, Francesco Brancati, Dina Di Giacomo

Abstract


Background: Albeit the genetic testing/counseling is increasing progressively in oncological clinical practice, psychological impact of BRCA genetic testing has been an under-researched area in oncological population; few studies have examined a wide range of possible predictive individual factors for psychological adaptation after genetic testing for hereditary cancer. Aim of the study was to examine the implication of clinical psychological in BRCA genetic result post-disclosure dealing with the emotional health of patients undergoing genetic testing depending to the personal resources.


Methods: Participants were composed of n = 32 female patients in range age 30 - 55 years, who have a BC diagnosis and who underwent BRCA mutation testing. Psychological battery was applied after genetic testing.


Results: Our finding highlighted the psychological influence of genetic testing on wellbeing of BC patients, and more drawing clinical perspective for positive/negative disclosure regarding the predictors for psychological distress.


Conclusion: Genetic testing needs to be integrated by psychological counseling to manage better the impact of result disclosure (whatever the outcome is) in order to manage better the physical and mental health of patients into efficient personalized medicine toward to the improvement of patient compliance and adherence into well-being perspective and Quality of Life maintaining. Sample size and lack of longitudinal data could be limits of the study.

Keywords


BRCA+/-; Psychological distress; Personality traits; Genetic testing; Psychological counseling; Breast cancer; Oncological clinical practice; Personalized medicine; Clinical psychology.

Full Text:

PDF

References


Akıncı, İ., Akyüz Yılmaz, C., & Bozo, Ö. Z. L. E. M. (2021). Dispositional Optimism and Well-being in Cancer Patients: The Role of CancerRelated Self-Efficacy. Mediterranean Journal of Clinical Psychology, 9(3). https://doi.org/10.13129/2282-1619/mjcp-3229

Bakos, A. D., Hutson, S. P., Loud, J. T., Peters, J. A., Giusti, R. M., & Greene, M. H. (2008). BRCA mutation-negative women from hereditary breast and ovarian cancer families: A qualitative study of the BRCA -negative experience. Health Expectations, 11(3), 220–231. https://doi.org/10.1111/j.1369-7625.2008.00494.x

Barchetta, S., Martino, G., Craparo, G., Salehinejad, M. A., Nitsche, M. A., & Vicario, C. M. (2021). Alexithymia Is Linked with a Negative Bias for Past and Current Events in Healthy Humans. International Journal of Environmental Research and Public Health, 18(13), 6696. https://doi.org/10.3390/ijerph18136696

Bjørnslett, M., Dahl, A. A., Sørebø, Ø., & Dørum, A. (2015). Psychological distress related to BRCA testing in ovarian cancer patients. Familial Cancer, 14(4), 495–504. https://doi.org/10.1007/s10689-015-9811-2

Blanchard-Fields, F., Stein, R., & Watson, T. L. (2004). Age Differences in Emotion-Regulation Strategies in Handling Everyday Problems. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 59(6), P261–P269. https://doi.org/10.1093/geronb/59.6.P261

Bosch, N., Junyent, N., Gadea, N., Brunet, J., Ramon y Cajal, T., Torres, A., Graña, B., Velasco, A., Darder, E., Mensa, I., & Balmaña, J. (2012a). What factors may influence psychological well being at three months and one year post BRCA genetic result disclosure? The Breast, 21(6), 755–760. https://doi.org/10.1016/j.breast.2012.02.004

Bosch, N., Junyent, N., Gadea, N., Brunet, J., Ramon y Cajal, T., Torres, A., Graña, B., Velasco, A., Darder, E., Mensa, I., & Balmaña, J. (2012b). What factors may influence psychological well being at three months and one year post BRCA genetic result disclosure? The Breast, 21(6), 755–760. https://doi.org/10.1016/j.breast.2012.02.004

Bottesi, G., Ghisi, M., Altoè, G., Conforti, E., Melli, G., & Sica, C. (2015). The Italian version of the Depression Anxiety Stress Scales-21: Factor structure and psychometric properties on community and clinical samples. Comprehensive Psychiatry, 60, 170–181. https://doi.org/10.1016/j.comppsych.2015.04.005

Cabrera, E., Blanco, I., Yagüe, C., & Zabalegui, A. (2010). The impact of genetic counseling on knowledge and emotional responses in Spanish population with family history of breast cancer. Patient Education and Counseling, 78(3), 382–388. https://doi.org/10.1016/j.pec.2009.10.032

Caputo, A., Vicario, C. M., Cazzato, V., & Martino, G. (2022). Editorial: Psychological Factors as Determinants of Medical Conditions, Volume II. Frontiers in Psychology, 13, 865235. https://doi.org/10.3389/fpsyg.2022.865235

Cella, D., Hughes, C., Peterman, A., Chang, C.-H., Peshkin, B. N., Schwartz, M. D., Wenzel, L., Lemke, A., Marcus, A. C., & Lerman, C. (2002). A brief assessment of concerns associated with genetic testing for cancer: The Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire. Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association, 21(6), 564–572.

Craparo, G., Faraci, P., Rotondo, G., & Gori, A. (2013). The Impact of Event Scale – Revised: Psychometric properties of the Italian version in a sample of flood victims. Neuropsychiatric Disease and Treatment, 1427. https://doi.org/10.2147/NDT.S51793

Di Giacomo, D., Jessica Ranieri, Federica Guerra, Enrico Perilli, Montserrat Gea Sánchez, Domenico Passafiume, Katia Cannita, & Corrado Ficorella. (2019). Survivorship in young women after early breast cancer: A cross-sectional study of emotional traits along 3-years perspective. Rivista Di Psichiatria, 2019July-August. https://doi.org/10.1708/3202.31798

Di Giuseppe, M., Miniati, M., Miccoli, M., Ciacchini, R., Orrù, G., Lo Sterzo, R., Di Silvestre, A., & Conversano, C. (2020). Defensive responses to stressful life events associated with cancer diagnosis. Mediterranean Journal of Clinical Psychology, Vol 8, No 1 (2020). https://doi.org/10.6092/2282-1619/mjcp-2384

Dwyer, A. A., Hesse‐Biber, S., Shea, H., Zeng, Z., & Yi, S. (2022). Coping response and family communication of cancer risk in men harboring a BRCA mutation: A mixed methods study. Psycho-Oncology, 31(3), 486–495. https://doi.org/10.1002/pon.5831

Faraci, P., Bottaro, R., & Craparo, G. (2021). Coping strategies and perceived social support among cancer patients: A cross-sectional analysis. Mediterranean Journal of Clinical Psychology, 9(1). https://doi.org/10.6092/2282-1619/mjcp-2892

Frisone, F., Sicari, F., Settineri, S., & Merlo, E. M. (2021). Clinical Psychological Assessment of Stress: A narrative review of the last 5 years. Clinical Neuropsychiatry, 18(2), 91–100. https://doi.org/10.36131/cnfioritieditore20210203

Graves, K. D., Vegella, P., Poggi, E. A., Peshkin, B. N., Tong, A., Isaacs, C., Finch, C., Kelly, S., Taylor, K. L., Luta, G., & Schwartz, M. D. (2012). Long-Term Psychosocial Outcomes of BRCA1 / BRCA2 Testing: Differences across Affected Status and Risk-Reducing Surgery Choice. Cancer Epidemiology, Biomarkers & Prevention, 21(3), 445–455. https://doi.org/10.1158/1055-9965.EPI-11-0991

Guido, G., Peluso, A. M., Capestro, M., & Miglietta, M. (2015). An Italian version of the 10-item Big Five Inventory: An application to hedonic and utilitarian shopping values. Personality and Individual Differences, 76, 135–140. https://doi.org/10.1016/j.paid.2014.11.053

Katapodi, M. C., Lee, K. A., Facione, N. C., & Dodd, M. J. (2004). Predictors of perceived breast cancer risk and the relation between perceived risk and breast cancer screening: A meta-analytic review. Preventive Medicine, 38(4), 388–402. https://doi.org/10.1016/j.ypmed.2003.11.012

Konstantinopoulos, P. A., Norquist, B., Lacchetti, C., Armstrong, D., Grisham, R. N., Goodfellow, P. J., Kohn, E. C., Levine, D. A., Liu, J. F., Lu, K. H., Sparacio, D., & Annunziata, C. M. (2020). Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline. Journal of Clinical Oncology, 38(11), 1222–1245. https://doi.org/10.1200/JCO.19.02960

Lausi, G., Quaglieri, A., Burrai, J., Mari, E., & Giannini, A. M. (2020). Development of the DERS-20 among the Italian population: A study for a short form of the Difficulties in Emotion Regulation Scale. Mediterranean Journal of Clinical Psychology, 8(2). https://doi.org/10.6092/2282-1619/mjcp-2511

Lemmo, D., Martino, M. L., & Freda, M. F. (2022). Cancer Prevention Sense Making and Metaphors in Young Women’s Invented Stories. Healthcare, 10(11), 2179. https://doi.org/10.3390/healthcare10112179

Lemmo, D., Martino, M. L., Vallone, F., Donizzetti, A. R., Freda, M. F., Palumbo, F., Lorenzo, E., D’Argenzio, A., & Caso, D. (2023). Clinical and psychosocial constructs for breast, cervical, and colorectal cancer screening participation: A systematic review. International Journal of Clinical and Health Psychology, 23(2), 100354. https://doi.org/10.1016/j.ijchp.2022.100354

Manchanda, R., Loggenberg, K., Sanderson, S., Burnell, M., Wardle, J., Gessler, S., Side, L., Balogun, N., Desai, R., Kumar, A., Dorkins, H., Wallis, Y., Chapman, C., Taylor, R., Jacobs, C., Tomlinson, I., McGuire, A., Beller, U., Menon, U., & Jacobs, I. (2015). Population Testing for Cancer Predisposing BRCA1/BRCA2 Mutations in the Ashkenazi-Jewish Community: A Randomized Controlled Trial. JNCI: Journal of the National Cancer Institute, 107(1). https://doi.org/10.1093/jnci/dju379

McCuaig, J. M., Thain, E., Malcolmson, J., Keshavarzi, S., Armel, S. R., & Kim, R. H. (2021). A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist- or Genetic Counselor-Mediated Model of Care. Current Oncology, 28(2), 1459–1471. https://doi.org/10.3390/curroncol28020138

Murdaca, G., Paladin, F., Casciaro, M., Vicario, C. M., Gangemi, S., & Martino, G. (2022). Neuro-Inflammaging and Psychopathological Distress. Biomedicines, 10(9), 2133. https://doi.org/10.3390/biomedicines10092133

Myles, L., & Merlo, Em. manuele. (2022). Incongruities between perceived control and desire for control: Accounting for depressive symptomology in adolescence. Psychiatria i Psychologia Kliniczna, 22(1), 40–44. https://doi.org/10.15557/PiPK.2022.0005

Popoviciu, M. S., Marin, V. N., Vesa, C. M., Stefan, S. D., Stoica, R. A., Serafinceanu, C., Merlo, E. M., Rizvi, A. A., Rizzo, M., Busnatu, S., & Stoian, A. P. (2022). Correlations between Diabetes Mellitus Self-Care Activities and Glycaemic Control in the Adult Population: A Cross-Sectional Study. Healthcare, 10(1), 174. https://doi.org/10.3390/healthcare10010174

Rahnea-Nita, R. A., Paunica, S., Motofei, C., & Rahnea-Nita, G. (2019). Assessment of anxiety and depression in patients with advanced gynaecological cancer. Mediterranean Journal of Clinical Psychology, 7(2). https://doi.org/10.6092/2282-1619/2019.7.2214

Rania, N., Migliorini, L., Vidili, M. G., Bianchetti, P., Forno, G., & Cavanna, D. (2018). Exploring well-being and satisfaction with physiotherapy efficacy: an Italian study of cancer patients. Mediterranean Journal of Clinical Psychology, 6(2). https://doi.org/10.6092/2282-1619/2018.6.1841

Ranieri, J., Fiasca, F., Guerra, F., Perilli, E., Mattei, A., & Di Giacomo, D. (2021). Examining the Post-operative Well-Being of Women Who Underwent Mammoplasty: A Cross-Sectional Study. Frontiers in Psychiatry, 12, 645102. https://doi.org/10.3389/fpsyt.2021.645102

The jamovi project. (2022). Jamovi (Version 2.3). https://www.jamovi.org/about.html

Tung, N. M., Boughey, J. C., Pierce, L. J., Robson, M. E., Bedrosian, I., Dietz, J. R., Dragun, A., Gelpi, J. B., Hofstatter, E. W., Isaacs, C. J., Jatoi, I., Kennedy, E., Litton, J. K., Mayr, N. A., Qamar, R. D., Trombetta, M. G., Harvey, B. E., Somerfield, M. R., & Zakalik, D. (2020). Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline. Journal of Clinical Oncology, 38(18), 2080–2106. https://doi.org/10.1200/JCO.20.00299

Vallone, F., Lemmo, D., Martino, M. L., Donizzetti, A. R., Freda, M. F., Palumbo, F., Lorenzo, E., D’Argenzio, A., & Caso, D. (2022). Factors promoting breast, cervical and colorectal cancer screenings participation: A systematic review. Psycho-Oncology, 31(9), 1435–1447. https://doi.org/10.1002/pon.5997

van Oostrom, I., Meijers-Heijboer, H., Lodder, L. N., Duivenvoorden, H. J., van Gool, A. R., Seynaeve, C., van der Meer, C. A., Klijn, J. G. M., van Geel, B. N., Burger, C. W., Wladimiroff, J. W., & Tibben, A. (2003). Long-Term Psychological Impact of Carrying a BRCA1/2 Mutation and Prophylactic Surgery: A 5-Year Follow-Up Study. Journal of Clinical Oncology, 21(20), 3867–3874. https://doi.org/10.1200/JCO.2003.10.100

Vicario, C. M., Martino, G., Lucifora, C., & Felmingham, K. (2022). Preliminary evidence on the neural correlates of timing deficit in post-traumatic stress disorder. European Journal of Psychotraumatology, 13(1), 2008151. https://doi.org/10.1080/20008198.2021.2008151

Voorwinden, J. S., & Jaspers, J. P. C. (2016). Prognostic Factors for Distress After Genetic Testing for Hereditary Cancer. Journal of Genetic Counseling, 25(3), 495–503. https://doi.org/10.1007/s10897-015-9894-9

Weiss D.S., Marmar C.R. (1997). Impact of Events Scale—Revised (IES-R). https://www.svri.org/sites/default/files/attachments/2016-01-13/Impact_of_Events_Scale_-_Revised__IES-R_.pdf

Wierenga, K. L., Lehto, R. H., & Given, B. (2017a). Emotion Regulation in Chronic Disease Populations: An Integrative Review. Research and Theory for Nursing Practice, 31(3), 247–271. https://doi.org/10.1891/1541-6577.31.3.247

Wierenga, K. L., Lehto, R. H., & Given, B. (2017b). Emotion Regulation in Chronic Disease Populations: An Integrative Review. Research and Theory for Nursing Practice, 31(3), 247–271. https://doi.org/10.1891/1541-6577.31.3.247

World Medical Association. (2008). WMA DECLARATION OF HELSINKI. https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/




DOI: https://doi.org/10.13129/2282-1619/mjcp-3805

Refbacks

  • There are currently no refbacks.