Effect of cognitive training on executive functions and anxiety in patients with mild cognitive impairment: a systematic review

Maria Alexandra Cardona Tangarife, Daniel Alfredo Landínez Martínez

Abstract


Introduction: Previous studies have reported changes in executive functions (working memory, inhibition, cognitive flexibility) and mood (anxiety and depression) in patients with Mild Cognitive Impairment (MCI). Different tools have shown to improve cognitive performance in this population, and computerized cognitive training is one of the most studied strategies. However, there is no consensus about near-transfer or far-transfer effects. Therefore, a systematic review is relevant for determining the effects of cognitive training on executive functions and mood. Aim: This systematic review aims to identify the effect of cognitive training on executive functions and anxiety in patients with MCI.


Methods: For the systematic search, the following search equation was used: “mild cognitive impairment” AND “executive functioning” AND “cognitive training” AND “anxiety”. We retrieved a total of 525 papers, but only 37 of them met the inclusion criteria. Articles published between January 2003 and February 2023 were included.


Results: The results revealed two research trends: (a) the effect of computerized cognitive training and virtual reality on executive functions and anxiety in people with MCI and (b) the effect of emerging intervention strategies on executive functions and anxiety in people with MCI. The effect of cognitive training on inhibitory control, working memory, reasoning, and attention was found to be predominant, even when it is not significant on all these variables. Studies on the effect of cognitive training on anxiety are still limited in number.


Conclusion: Conducting longitudinal studies is necessary to understand the effect and underlying mechanisms of cognitive training.


Keywords


Anxiety; Cognitive training; Executive functioning; Mild cognitive impairment.

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References


American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). https://doi.org/10.1176/appi.books.9780890425596

Bahar-Fuchs, A., Webb, S., Bartsch, L., Clare, L., Rebok, G., Cherbuin, N., & Anstey, K. J. (2017). Tailored and Adaptive Computerized Cognitive Training in Older Adults at Risk for Dementia: A Randomized Controlled Trial. Journal of Alzheimer’s Disease, 60(3), 889–911. https://doi.org/10.3233/JAD-170404

Antonenko, D., Fromm, A. E., Thams, F., Kuzmina, A., Backhaus, M., Knochenhauer, E., Li, S. C., Grittner, U., & Flöel, A. (2024). Cognitive training and brain stimulation in patients with cognitive impairment: a randomized controlled trial. Alzheimer’s Research and Therapy, 16(1). https://doi.org/10.1186/s13195-024-01381-3

Apostolova, L. G., Dinov, I. D., Dutton, R. A., Hayashi, K. M., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2006). 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer’s disease. Brain, 129(11), 2867–2873. https://doi.org/10.1093/brain/awl274

Bahar-Fuchs, A., Webb, S., Bartsch, L., Clare, L., Rebok, G., Cherbuin, N., & Anstey, K. J. (2017). Tailored and Adaptive Computerized Cognitive Training in Older Adults at Risk for Dementia: A Randomized Controlled Trial. Journal of Alzheimer’s Disease, 60(3), 889–911. https://doi.org/10.3233/JAD-170404

Baik, J. S., Min, J. H., Ko, S. H., Yun, M. S., Lee, B., Kang, N. Y., Kim, B., Lee, H., & Shin, Y. I. (2024). Effects of Home-Based Computerized Cognitive Training in Community-Dwelling Adults with Mild Cognitive Impairment. IEEE Journal of Translational Engineering in Health and Medicine, 12, 97–105. https://doi.org/10.1109/JTEHM.2023.3317189

Bampa, G., Moraitou, D., Metallidou, P., Masoura, E., Papantoniou, G., Sofologi, M., Kougioumtzis, G. A., & Tsolaki, M. (2024). The Efficacy of a Metacognitive Training Program in Amnestic Mild Cognitive Impairment: A 6-Month Follow-Up Clinical Study. Healthcare (Switzerland), 12(10). https://doi.org/10.3390/healthcare12101019

Baquero, M., Blasco, R., Campos-García, A., Garcés, M., Fages, E. M., & Andreu-Català, M. (2004). Descriptive study of behavioural disorders in mild cognitive impairment. Revista de Neurologia, 38(4), 323–326. https://doi.org/10.33588/rn.3804.2003541

Barban, F., Annicchiarico, R., Pantelopoulos, S., Federici, A., Perri, R., Fadda, L., Carlesimo, G. A., Ricci, C., Giuli, S., Scalici, F., Turchetta, C. S., Adriano, F., Lombardi, M. G., Zaccarelli, C., Cirillo, G., Passuti, S., Mattarelli, P., Lymperopoulou, O., Sakka, P., … Caltagirone, C. (2016). Protecting cognition from aging and Alzheimer’s disease: A computerized cognitive training combined with reminiscence therapy. International Journal of Geriatric Psychiatry, 31(4), 340–348. https://doi.org/10.1002/gps.4328

Barnes, D. E., Yaffe, K., Belfor, N., Jagust, W. J., DeCarli, C., Reed, B. R., & Kramer, J. H. (2009). Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial. Alzheimer Disease & Associated Disorders, 23(3), 205-210. https://doi.org/10.1097/WAD.0b013e31819c6137

Belleville, S., Clément, F., Mellah, S., Gilbert, B., Fontaine, F., & Gauthier, S. (2011). Training-related brain plasticity in subjects at risk of developing Alzheimer’s disease. Brain, 134(6), 1623–1634. https://doi.org/10.1093/brain/awr037

Belleville, S., Cloutier, S., Mellah, S., Willis, S., Vellas, B., Andrieu, S., Coley, N., & Ngandu, T. (2022). Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia. Alzheimer’s and Dementia, 18(11), 2140–2150. https://doi.org/10.1002/alz.12544

Belleville, S., Gilbert, B., Fontaine, F., Gagnon, L., Ménard, É., & Gauthier, S. (2006). Improvement of episodic memory in persons with mild cognitive impairment and healthy older adults: Evidence from a cognitive intervention program. Dementia and Geriatric Cognitive Disorders, 22(5–6), 486–499. https://doi.org/10.1159/000096316

Chan, A. T. C., Ip, R. T. F., Tran, J. Y. S., Chan, J. Y. C., & Tsoi, K. K. F. (2024). Computerized cognitive training for memory functions in mild cognitive impairment or dementia: a systematic review and meta-analysis. NPJ digital medicine, 7(1), 1. https://doi.org/10.1038/s41746-023-00987-5

Chen, Q., Turnbull, A., Cole, M., Zhang, Z., & Lin, F. V. (2022). Enhancing cortical network-level participation coefficient as a potential mechanism for transfer in cognitive training in aMCI. NeuroImage, 254. https://doi.org/10.1016/j.neuroimage.2022.119124

Cilli, E., Ranieri, J., Guerra, F., Colicchia, S., & Di Giacomo, D. (2023). Digital affinitiy and cognitive reserve: Salience for resilient aging in pandemic. Gerontology & geriatric medicine, 9, 23337214231162773. https://doi.org/10.1177/23337214231162773

Corbo, I., & Casagrande, M. (2022). Higher-Level Executive Functions in Healthy Elderly and Mild Cognitive Impairment: A Systematic Review. Journal of Clinical Medicine, 11(5), 1204-1204. https://doi.org/10.3390/jcm11051204

De Sousa, A. V. C., Grittner, U., Rujescu, D., Külzow, N., & Flöel, A. (2020). Impact of 3-Day Combined Anodal Transcranial Direct Current Stimulation-Visuospatial Training on Object-Location Memory in Healthy Older Adults and Patients with Mild Cognitive Impairment. Journal of Alzheimer’s Disease, 75(1), 223–244. https://doi.org/10.3233/jad-191234

Del Signore, F., Rosi, A., Palumbo, R., Allegri, N., Costa, A., Govoni, S., & Cavallini, E. (2023). Capacity to consent to research in older adults with normal cognitive functioning, mild and major neurocognitive disorder: an Italian study. Mediterranean Journal of Clinical Psychology 11(1). https://doi.org/10.13129/2282-1619/mjcp-3620

Dwolatzky, T., Feuerstein, R. S., Manor, D., Cohen, S., Devisheim, H., Inspector, M., Eran, A., & Tzuriel, D. (2021). Changes in brain volume resulting from cognitive intervention by means of the feuerstein instrumental enrichment program in older adults with mild cognitive impairment (Mci): A pilot study. Brain Sciences, 11(12). https://doi.org/10.3390/brainsci11121637

Finn, M., & McDonald, S. (2011). Computerised cognitive training for older persons with mild cognitive impairment: a pilot study using a randomised controlled trial design. Brain Impairment, 12(3), 187-199. https://doi.org/10.1375/brim.12.3.187.

Frisoni, G. B., Altomare, D., Ribaldi, F., Villain, N., Brayne, C., Mukadam, N., Abramowicz, M., Barkhof, F., Berthier, M., Bieler-Aeschlimann, M., Blennow, K., Brioschi Guevara, A., Carrera, E., Chételat, G., Csajka, C., Demonet, J. F., Dodich, A., Garibotto, V., Georges, J., … Dubois, B. (2023). Dementia prevention in memory clinics: recommendations from the European task force for brain health services. In The Lancet Regional Health - Europe (Vol. 26). Elsevier Ltd. https://doi.org/10.1016/j.lanepe.2022.100576

Gagnon, L. G., & Belleville, S. (2012). Training of attentional control in mild cognitive impairment with executive deficits: Results from a double-blind randomised controlled study. Neuropsychological Rehabilitation, 22(6), 809–835. https://doi.org/10.1080/09602011.2012.691044

Gajewski, P. D., Thönes, S., Falkenstein, M., Wascher, E., & Getzmann, S. (2020). Multidomain Cognitive Training Transfers to Attentional and Executive Functions in Healthy Older Adults. Frontiers in Human Neuroscience, 14. https://doi.org/10.3389/fnhum.2020.586963

Geda, Y. E., Roberts, R. O., Mielke, M. M., Knopman, D. S., Christianson, T. J., Pankratz, V. S., ... & Rocca, W. A. (2014). Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: a population-based study. American Journal of Psychiatry, 171(5), 572-581. https://doi.org/10.1176/appi.ajp.2014.13060821

Givon Schaham, N., Buckman, Z., & Rand, D. (2024). TECH preserves global cognition of older adults with MCI compared with a control group: a randomized controlled trial. Aging Clinical and Experimental Research, 36(1). https://doi.org/10.1007/s40520-023-02659-6

Grimaud, E., Clarys, D., Vanneste, S., & Taconnat, L. (2021). Cognitive stimulation in healthy elderly: Effects of a cognitive stimulation program using games on cognitive functions and self-esteem. Psychologie Francaise, 66(2), 173–186. https://doi.org/10.1016/j.psfr.2019.11.002

Henao Arboleda, E., Aguirre Acevedo, D. C., Muñoz, C., Pineda Salazar, D. A., & Lopera Restrepo, F. (2008). Prevalencia de deterioro cognitivo leve de tipo amnésico en una población colombiana. Revista de Neurología, 46(12), 709. https://doi.org/10.33588/rn.4612.2007569

Herrera, C., Chambon, C., Michel, B. F., Paban, V., & Alescio-Lautier, B. (2012). Positive effects of computer-based cognitive training in adults with mild cognitive impairment. Neuropsychologia, 50(8), 1871–1881. https://doi.org/10.1016/j.neuropsychologia.2012.04.012

Hirsch, J. E. (2005). An index to quantify an individual's scientific research output. Proceedings of the National academy of Sciences, 102(46), 16569-16572. https://doi.org/10.1073/pnas.0507655102

Hwang, T. J., Masterman, D. L., Ortiz, F., Fairbanks, L. A., & Cummings, J. L. (2004). Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms. Alzheimer Disease & Associated Disorders, 18(1), 17-21. https://doi.org/10.1097/00002093-200401000-00004

Innes, K. E., Montgomery, C., Selfe, T. K., Wen, S., Khalsa, D. S., & Flick, M. (2021). Incorporating a Usual Care Comparator into a Study of Meditation and Music Listening for Older Adults with Subjective Cognitive Decline: A Randomized Feasibility Trial. Journal of Alzheimer’s Disease Reports, 5(1), 187–206. https://doi.org/10.3233/ADR-200249

Jahouh, M., González-Bernal, J. J., González-Santos, J., Fernández-Lázaro, D., Soto-Cámara, R., & Mielgo-Ayuso, J. (2021). Impact of an intervention with wii video games on the autonomy of activities of daily living and psychological–cognitive components in the institutionalized elderly. International Journal of Environmental Research and Public Health, 18(4), 1–14. https://doi.org/10.3390/ijerph18041570

Jhaveri, S., Romanyk, M., Glatt, R., & Satchidanand, N. (2023). SMARTfit Dual-Task Exercise Improves Cognition and Physical Function in Older Adults With Mild Cognitive Impairment: Results of a Community-Based Pilot Study. Journal of Aging and Physical Activity, 31(4), 621–632. https://doi.org/10.1123/japa.2022-0040

Kang, J. M., Kim, N., Lee, S. Y., Woo, S. K., Park, G., Yeon, B. K., Park, J. W., Youn, J. H., Ryu, S. H., Lee, J. Y., & Cho, S. J. (2021). Effect of cognitive training in fully immersive virtual reality on visuospatial function and frontal-occipital functional connectivity in predementia: Randomized controlled trial. Journal of Medical Internet Research, 23(5). https://doi.org/10.2196/24526

Kim, H., Hong, J. P., Kang, J. M., Kim, W. H., Maeng, S., Cho, S. E., Na, K. S., Oh, S. H., Park, J. W., Cho, S. J., & Bae, J. N. (2021). Cognitive reserve and the effects of virtual reality-based cognitive training on elderly individuals with mild cognitive impairment and normal cognition. Psychogeriatrics, 21(4), 552–559. https://doi.org/10.1111/psyg.12705

Klyucherev, T. O., Olszewski, P., Shalimova, A. A., Chubarev, V. N., Tarasov, V. V., Attwood, M. M., Syvänen, S., & Schiöth, H. B. (2022). Advances in the development of new biomarkers for Alzheimer’s disease. Translational Neurodegeneration, 11(1), 25. https://doi.org/10.1186/s40035-022-00296-z

Lee, K. T., Wang, W. L., Lin, W. C., Yang, Y. C., & Tsai, C. L. (2022). The Effects of a Magic Intervention Program on Cognitive Function and Neurocognitive Performance in Elderly Individuals With Mild Cognitive Impairment. Frontiers in Aging Neuroscience, 14. https://doi.org/10.3389/fnagi.2022.854984.

Liao, Y. Y., Hsuan Chen, I., Lin, Y. J., Chen, Y., & Hsu, W. C. (2019). Effects of virtual reality-based physical and cognitive training on executive function and dual-task gait performance in older adults with mild cognitive impairment: A randomized control trial. Frontiers in Aging Neuroscience, 10(JUL). https://doi.org/10.3389/fnagi.2019.00162

Liao, Y. Y., Tseng, H. Y., Lin, Y. J., Wang, C. J., & Hsu, W. C. (2020). Using virtual reality-based training to improve cognitive function, instrumental activities of daily living and neural efficiency in older adults with mild cognitive impairment. European Journal of Physical and Rehabilitation Medicine, 56(1), 47–57. https://doi.org/10.23736/S1973-9087.19.05899-4

Luo, Y., Lin, R., Yan, Y., Li, Y., Huang, C., Chen, M., & Li, H. (2024). Maintenance effects of short-period intensive creative expressive arts-based program (SPI-CrEAS) on cognitive function older adults with mild cognitive impairment: A pilot study. Geriatric Nursing, 59, 170–180. https://doi.org/10.1016/j.gerinurse.2024.06.034

Lyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J., & DeKosky, S. (2002). Prevalence of Neuropsychiatric Symptoms in Dementia and Mild Cognitive Impairment. JAMA, 288(12), 1475. https://doi.org/10.1001/jama.288.12.1475

Mah, L., Binns, M. A., & Steffens, D. C. (2015). Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease. American Journal of Geriatric Psychiatry, 23(5), 466–476. https://doi.org/10.1016/j.jagp.2014.10.005

Manenti, R., Baglio, F., Pagnoni, I., Gobbi, E., Campana, E., Alaimo, C., ... & Cotelli, M. (2024). Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study. Frontiers in Aging Neuroscience, 16, 1414593. https://doi.org/10.3389/fnagi.2024.1414593

Marin, A., DeCaro, R., Schiloski, K., Elshaar, A., Dwyer, B., Vives-Rodriguez, A., Palumbo, R., Turk, K., & Budson, A. (2022). Home-Based Electronic Cognitive Therapy in Patients With Alzheimer Disease: Feasibility Randomized Controlled Trial. JMIR Formative Research, 6(9). https://doi.org/10.2196/34450

Martínez Morales, D., Montoya Arenas, A. D., Landínez Martínez, D. (2023). Working memory training with technological innovation in older adults with mild neurocognitive disorder: a systematic review using ToS (Tree of Science) methodology. Mediterranean Journal of Clinical Psychology 11(3). https://doi.org/10.13129/2282-1619/mjcp-3884

McDougall, G. J., McDonough, I. M., & LaRocca, M. (2019). Memory training for adults with probable mild cognitive impairment: a pilot study. Aging & Mental Health, 23(10), 1433-1441. https://doi.org/10.1080/13607863.2018.1484884

Miao, D., Zhou, X., Wu, X., Chen, C., & Tian, L. (2022). Hippocampal morphological atrophy and distinct patterns of structural covariance network in Alzheimer’s disease and mild cognitive impairment. Frontiers in Psychology, 13. https://doi.org/10.3389/fpsyg.2022.980954

Montero-Odasso, M., Zou, G., Speechley, M., Almeida, Q. J., Liu-Ambrose, T., Middleton, L. E., Camicioli, R., Bray, N. W., Li, K. Z. H., Fraser, S., Pieruccini-Faria, F., Berryman, N., Lussier, M., Shoemaker, J. K., Son, S., & Bherer, L. (2023). Effects of Exercise Alone or Combined with Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults with Mild Cognitive Impairment: A Randomized Clinical Trial. JAMA Network Open, 6(7), E2324465. https://doi.org/10.1001/jamanetworkopen.2023.2446

Moutoussamy, I., Taconnat, L., Pothier, K., Toussaint, L., & Fay, S. (2022). Episodic memory and aging: Benefits of physical activity depend on the executive resources required for the task. PLoS ONE, 17(2 February). https://doi.org/10.1371/journal.pone.0263919

National Institute on Aging. (n.d.). ¿Qué es el deterioro cognitivo leve? Https://Www.Nia.Nih.Gov/Health/Memory-Loss-and-Forgetfulness/What-Mild-Cognitive-Impairment

Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., Lindström, J., Mangialasche, F., Paajanen, T., Pajala, S., Peltonen, M., Rauramaa, R., Stigsdotter-Neely, A., Strandberg, T., Tuomilehto, J., … Kivipelto, M. (2015). A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial. The Lancet, 385(9984), 2255–2263. https://doi.org/10.1016/S0140-6736(15)60461-5

Nobari, H., Rezaei, S., Sheikh, M., García, J. P. F., & Pérez-Gómez, J. (2021). Effect of virtual reality exercises on the cognitive status and dual motor task performance of the aging population. International Journal of Environmental Research and Public Health, 18(15). https://doi.org/10.3390/ijerph18158005

Nousia, A., Martzoukou, M., Siokas, V., Aretouli, E., Aloizou, A. M., Folia, V., Peristeri, E., Messinis, L., Nasios, G., & Dardiotis, E. (2021). Beneficial effect of computer-based multidomain cognitive training in patients with mild cognitive impairment. Applied Neuropsychology:Adult, 28(6), 717–726. https://doi.org/10.1080/23279095.2019.1692842

Nousia, A., Pappa, E., Siokas, V., Liampas, I., Tsouris, Z., Messinis, L., Patrikelis, P., Manouilidou, C., Dardiotis, E., & Nasios, G. (2023). Evaluation of the Efficacy and Feasibility of a Telerehabilitation Program Using Language and Cognitive Exercises in Multi-Domain Amnestic Mild Cognitive Impairment. Archives of Clinical Neuropsychology : The Official Journal of the National Academy of Neuropsychologists, 38(2), 224–235. https://doi.org/10.1093/arclin/acac078

Papp, K. V., Snyder, P. J., Maruff, P., Bartkowiak, J., & Pietrzak, R. H. (2011). Detecting Subtle Changes in Visuospatial Executive Function and Learning in the Amnestic Variant of Mild Cognitive Impairment. PLoS ONE, 6(7), e21688. https://doi.org/10.1371/journal.pone.0021688

Park, E. A., Jung, A. R., & Lee, K. A. (2021). The humanoid robot sil-bot in a cognitive training program for community-dwelling elderly people with mild cognitive impairment during the COVID-19 pandemic: A randomized controlled trial. International Journal of Environmental Research and Public Health, 18(15). https://doi.org/10.3390/ijerph18158198

Park, J. H. (2022). Effects of Spatial Cognitive Training Using Virtual Reality on Hippocampal Functions and Prefrontal Cortex Activity in Older Adults with Mild Cognitive Impairment. International Journal of Gerontology, 16(3), 242–246. https://doi.org/10.6890/IJGE.202207_16(3).0014

Park, J. H., Liao, Y., Kim, D. R., Song, S., Lim, J. H., Park, H., Lee, Y., & Park, K. W. (2020). Feasibility and tolerability of a culture-based virtual reality (VR) training program in patients with mild cognitive impairment: A randomized controlled pilot study. International Journal of Environmental Research and Public Health, 17(9). https://doi.org/10.3390/ijerph17093030

Pedraza, O. L., Montes, A. M. S., Sierra, F. A., Montalvo, M. C., Muñoz, Y., Díaz, J. M., Lozano, A., & Piñeros, C. (2017). Mild cognitive impairment (MCI) and dementia in a sample of adults in the city of Bogotá. Dementia e Neuropsychologia, 11(3), 262–269. https://doi.org/10.1590/1980-57642016dn11-030008

Petersen, R. C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256(3), 183–194. https://doi.org/10.1111/j.1365-2796.2004.01388.

Petersen, R. C., Caracciolo, B., Brayne, C., Gauthier, S., Jelic, V., & Fratiglioni, L. (2014). Mild cognitive impairment: A concept in evolution. Journal of Internal Medicine, 275(3), 214–228. https://doi.org/10.1111/joim.12190

Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001). Current Concepts in Mild Cognitive Impairment. Arch Neurol, 58(12), 1985–1992. https://doi.org/10.1001/archneur.58.12.1985

Petersen, R. C., Lopez, O., Armstrong, M. J., Getchius, T. S. D., Ganguli, M., Gloss, D., Gronseth, G. S., Marson, D., Pringsheim, T., Day, G. S., Sager, M., Stevens, J., & Rae-Grant, A. (2018). Practice guideline update summary: Mild cognitive impairment report of theguideline development, dissemination, and implementation. Neurology, 90(3), 126–135. https://doi.org/10.1212/WNL.0000000000004826

Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999). Mild Cognitive Impairment Clinical Characterization and Outcome. Acta Neurol, 56, 303–308. https://doi.org/10.1001/archneur.56.3.303

Pikouli, F. A., Moraitou, D., Papantoniou, G., Sofologi, M., Papaliagkas, V., Kougioumtzis, G., Poptsi, E., & Tsolaki, M. (2023). Metacognitive Strategy Training Improves Decision-Making Abilities in Amnestic Mild Cognitive Impairment. Journal of Intelligence, 11(9). https://doi.org/10.3390/jintelligence11090182

Rebok, G. W., Ball, K., Guey, L. T., Jones, R. N., Kim, H. Y., King, J. W., Marsiske, M., Morris, J. N., Tennstedt, S. L., Unverzagt, F. W., & Willis, S. L. (2014). Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults. Journal of the American Geriatrics Society, 62(1), 16–24. https://doi.org/10.1111/jgs.12607

Restrepo de Mejía, R., Segura G. M., Medina S. L. F., Méndez R. S., Murillo Rendón C., Márquez Narváez L. P., Quintero C. V., Álvarez D., & Henao D.F.. (2020). Su prevalencia y relación con factores Deterioro cognitivo en Caldas (Editorial UAM).

Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines. Geneva: World Health Organization. (2019). Avalilable in: https://www.ncbi.nlm.nih.gov/books/NBK542796/#

Robledo, S., Osorio, G. A., & López, C. (2014). Networking en pequeña empresa: una revisión bibliográfica utilizando la teoría de grafos. Revista Vínculos, 11(4), 6–16. https://doi.org/10.14483/2322939X.9664

Rosenberg, P. B., Mielke, M. M., Appleby, B., Oh, E., Leoutsakos, J. M., & Lyketsos, C. G. (2011). Neuropsychiatric symptoms in MCI subtypes: The importance of executive dysfunction. International Journal of Geriatric Psychiatry, 26(4), 364–372. https://doi.org/10.1002/gps.2535

Rozzini, L., Costardi, D., Chilovi, V., Franzoni, S., Trabucchi, M., & Padovani, A. (2007). Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors. International Journal of Geriatric Psychiatry, 22(4), 356–360. https://doi.org/10.1002/gps.1681

Sachdev, P. S., Lipnicki, D. M., Kochan, N. A., Crawford, J. D., Thalamuthu, A., Andrews, G., ... & Cohort Studies of Memory in an International Consortium (COSMIC). (2015). The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC collaboration. PloS one, 10(11), e0142388. https://doi.org/10.1371/journal.pone.0142388

Satorres, E., Escudero Torrella, J., Real, E., Pitarque, A., Delhom, I., & Melendez, J. C. (2023). Home-based transcranial direct current stimulation in mild neurocognitive disorder due to possible Alzheimer’s disease. A randomised, single-blind, controlled-placebo study. Frontiers in Psychology, 13. https://doi.org/10.3389/fpsyg.2022.1071737

Saunders, N., & Summers, M. (2010). Attention and working memory deficits in mild cognitive impairment. Journal of Clinical and Experimental Neuropsychology, 32(4), 350–357. https://doi.org/10.1080/13803390903042379

Steinberg, M., Shao, H., Zandi, P., Lyketsos, C. G., Welsh‐Bohmer, K. A., Norton, M. C., ... & Tschanz, J. T. (2008). Point and 5‐year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study. International Journal of Geriatric Psychiatry: A journal of the psychiatry of late life and allied sciences, 23(2), 170-177. https://doi.org/10.1002/gps.1858

Tawfik, H. M., Tsatali, M., & Hassanin, H. I. (2022). Pilot feasibility study of cognitive training exercises for Egyptian adults: Proof of concept. International Journal of Geriatric Psychiatry, 37(1). https://doi.org/10.1002/gps.5624

Thapa, N., Park, H. J., Yang, J. G., Son, H., Jang, M., Lee, J., Kang, S. W., Park, K. W., & Park, H. (2020). The effect of a virtual reality-based intervention program on cognition in older adults with mild cognitive impairment: A randomized control trial. Journal of Clinical Medicine, 9(5). https://doi.org/10.3390/jcm9051283

Tinello, D., Tarvainen, M., Zuber, S., & Kliegel, M. (2023). Enhancing Inhibitory Control in Older Adults: A Biofeedback Study. Brain Sciences, 13(2). https://doi.org/10.3390/brainsci13020335

Tripathi, R., Kumar, K., Balachandar, R., Marimuthu, P., Varghese, M., & Bharath, S. (2015). Neuropsychological markers of mild cognitive impairment: A clinic based study from urban India. Annals of Indian Academy of Neurology, 18(2), 177–180. https://doi.org/10.4103/0972-2327.150566

Urbanowitsch, N., Degen, C., Toro, P., & Schröder, J. (2015). Neurological soft signs in aging, mild cognitive impairment, and Alzheimer’s disease - the impact of cognitive decline and cognitive reserve. Frontiers in Psychiatry, 6(FEB). https://doi.org/10.3389/fpsyt.2015.00012

Ward, A., Arrighi, H. M., Michels, S., & Cedarbaum, J. M. (2012). Mild cognitive impairment: Disparity of incidence and prevalence estimates. Alzheimer’s and Dementia, 8(1), 14–21. https://doi.org/10.1016/j.jalz.2011.01.002

Willis, S. L., Tennstedt, S. L., Marsiske, M., Ball, K., Elias, J., Mann Koepke, K., Morris, J. N., Rebok, G. W., Unverzagt, F. W., Stoddard, A. M., & Wright, E. (2006). Long-term Effects of Cognitive Training on Everyday Functional Outcomes in Older Adults. JAMA, 296(23). https://doi.org/10.1001/jama.296.23.2805

Wong, Y. K., Wu, C. F., & Tu, Y. H. (2022). Effectiveness of a Serious Game Design and Game Mechanic Factors for Attention and Executive Function Improvement in the Elderly: A Pretest-Posttest Study. Applied Sciences (Switzerland), 12(14). https://doi.org/10.3390/app12146923

World Health Organization. (2017). Global action plan on the public health response to dementia 2017–2025. World Health Organization. http://apps.who.int/bookorders.

Wu, J., He, Y., Liang, S., Liu, Z., Huang, J., Liu, W., Tao, J., Chen, L., Chan, C. C. H., & Lee, T. M. C. (2023). Effects of computerized cognitive training on structure‒function coupling and topology of multiple brain networks in people with mild cognitive impairment: a randomized controlled trial. Alzheimer’s Research and Therapy, 15(1). https://doi.org/10.1186/s13195-023-01292-9

Yanmin, Z., Buxin, H., Verhaeghen, P., & Lars Göran, N. (2007). Executive functioning in older adults with mild cognitive impairment: MCI has effects on planning, but not on inhibition. Aging, Neuropsychology, and Cognition, 14(6), 557–570. https://doi.org/10.1080/13825580600788118

Yuan, L. Q., Zeng, Q., Wang, D., Wen, X. Y., Shi, Y., Zhu, F., Chen, S. J., & Huang, G. Z. (2021). Neuroimaging mechanisms of high-frequency repetitive transcranial magnetic stimulation for treatment of amnestic mild cognitive impairment: A double-blind randomized sham-controlled trial. Neural Regeneration Research, 16(4), 707–713. https://doi.org/10.4103/1673-5374.295345

Zhang, X., Ren, H., Pei, Z., Lian, C., Su, X. L., Lan, X., Chen, C., Lei, Y. H., Li, B., & Guo, Y. (2022). Dual-targeted repetitive transcranial magnetic stimulation modulates brain functional network connectivity to improve cognition in mild cognitive impairment patients. Frontiers in Physiology, 13. https://doi.org/10.3389/fphys.2022.1066290




DOI: https://doi.org/10.13129/2282-1619/mjcp-4092

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